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Mom's Locket est un bijou ajouté dans l’extension Afterbirth.
- Grants half a red heart each time a key is used.
- Turns half red hearts on the ground into full red hearts.
- Having a Golden Key will render the trinket unable to grant half hearts from keys until the next floor.
- Having Mom's Locket while playing Keeper will restore a full health coin when a key is used.
- Dark Bum - Gives the bum more hearts to turn into soul hearts, which is very useful for a ??? run.
- Gimpy - Half hearts dropped occasionally from killing enemies will become full hearts.
- Guppy's Tail - Increases chance of getting golden chests, giving Isaac more locks to open.
- Humbling Bundle - Turns half Hearts into 1+1 Hearts.
- Little C.H.A.D. - Changes Little C.H.A.D.'s half hearts into full hearts.
- Skeleton Key - Gives Isaac a lot of keys to spend.