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Serpent's Kiss is a passive item added in Afterbirth.



  • Grants poison tears, dealing damage over time when inflicted.
  • Inflicts poison on enemies who make contact with the character.
  • Enemies who are killed by poison damage have a chance to drop Black Hearts.


  • The contact and poison effects of this item are identical to The Virus, but does not include a Speed down.
  • This item and The Virus are the two only poison sources to have a chance to drop black hearts.


  • Athame: The black ring created by the Athame applies the poison from Serpent's Kiss. This means enemies killed will have a higher chance to drop black hearts.
  • Invulnerability: Contact while invincible poisons enemies.
  • Scorpio: Grants the character a 100% chance of firing poison tears.
  • Second Hand: Extends the duration that enemies stay poisoned, dealing more damage over time.
  • Soy Milk: The low damage and high fire rate increases the chance of enemies and bosses being poisoned.
  • Tech X: Since Tech X deals its damage quickly, it's more likely to deal the killing blow to enemies reducing the chance of black hearts dropping.
  • The Common Cold: Adds to the chance of firing poison tears, based on the character's Luck stat.

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