| Transformations |
| Guppy | Belzébuth |  Super Mendiant
|
Oui Maman ?
|
Bob
|
Fan de Spore
|
Léviathan
|
Siamois
|
| Addict
|
Séraphin
|
Crotte Alors
|
 Rat de Bibliothèque
|
Homme Araignée
|
Adulte
|
Poids Lourd
|
Isaac se transforme en son chat Guppy après avoir ramassé trois éléments distincts dans la liste suivante. Sous cette forme, Isaac gagne Flight et engendrera des blue fly chaque fois qu'un ennemi est frappé avec une larme.
Activated Collectibles
Modèle:Guppy's HeadModèle:Guppy's Paw| Item | Icon | Effect | Recharge |
|---|
Passive Collectibles
Modèle:Dead CatModèle:Guppy's CollarModèle:Guppy's TailModèle:Guppy's Hair Ball| Item | Icon | Effect |
|---|
Seeds Modèle:NoUnlocks
Modèle:PlatPC XWN6 1YWH (Basement 1 - Curse Room above spawn contains 2 Red Chests and Stone Chest, Guppy's Collar, Guppy's Head and Dead Cat respectively, Normal only) Modèle:PlatPC 7TC3 43F1 (Basement 1 - Curse Room above spawn contains 2 Red Chests and Stone Chest, Guppy's Collar, Guppy's Paw and Guppy's Head respectively, Normal only) Modèle:PlatPC 7PTQ 2DVK (Basement I - requires D6 - Curse Room contains Dead Cat and Guppy's Paw, reroll Guppy's Paw into Guppy's Tail. Next to spawn on hard mode, two rooms left on normal mode.) Modèle:PlatPC JGE8 MVA6 (Basement I - Curse Room contains Guppy's Tail and a teleport to the Devil Room, which contains Dead Cat and Death's Touch that can be rerolled into Guppy's Paw) Modèle:PlatPC ZVEZ K10X (Basement I - Curse room to the left of the spawn contains guppy's head and Dead Cat in the red chests, Using the D6 on the head will change it to Guppy's Paw) Modèle:PlatPC FS0R WNL1 (Basement I - Curse room above spawn room contains guppy's tail and guppy's paw. Using the D6 after picking up guppy's paw will reroll to guppy's head. Item room also contains Polyphemus) Modèle:PlatPS4 7PTQ 2DVK (Basement I - Have D6 unlocked, go to the Curse Room just below spawn, take the 2 guppy items and reroll Guppy's Paw into Guppy's Tail)
Modèle:NavPrincipale